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KMID : 0615719990160040283
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Jouranl of Korean Acupuncture and Moxibustion society
1999 Volume.16 No. 4 p.283 ~ p.291
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Effect of electroacupuncture on NADPH - diaphorase and neuropeptide Y neurons in cerebral cortex of SHR rats
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Abstract
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The aim of this study is to investigate the effect of electroacupuncture on NADPH-diaphorase and neuropeptide Y neurons in cerebral cortex of SHR rats.
We evaluated the changes of NADPH-d-positive neurons using a histochemical method. Staining intensities of NADPH-d-positive neurons were assessed in a quantitative fashion using a microdensitometrical method based on optical density by means of an image analyzer. In addition, we examined the change of neuropeptide Y (NPY) since this substance is involved in cerebral blood flow.
Electroacupuncture treatments significantly increased the optical density of NADPH-d in comparison to the normal group in most cortical areas. The optical density of NADPH-d-positive neurons of Shinsu and Choksamni electroacupuncture group was significandy decreased in comparison to arbitrary group. However, the optical density of NPY-IR neurons was not significandy changed in most cortical areas of electroacupuncture groups except in the secondary motor cortex and cingulate cortex of Choksamni electroacupucnture group. Although the optical density of NPY-IR neurons was conserved across many cortical areas of electroacupuncture groups, we observed a decrease in the optical density of NPY-IR neurons in some cortical regions of aged rats. Therefore, NPY-IR neurons in various regions of the cerebral cortex may be differentially affected by electroacupuncture.
It is concluded that the morphological evidence for NADPH-d-positive neurons may be more susceptible to electroacupuncture treatment related change than NPY-IR neurons in the cerebral cortex.
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